A Phase II Study to Treat Subjects with Advanced Renal Cell Carcinoma

- documented histologically confirmed advanced or metastatic renal cell carcinoma with the primary tumor in place or following nephrectomy - measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques (CT or MRI) or ≥ 10 mm by spiral CT scan - no more than 3 relapses (or prior systemic treatments) - unable to receive or failed prior therapy with vascular endothelial growth factor (VEGF) binding agents or VEGF receptor tyrosine kinase inhibitors or other multi-kinase inhibitors - tissue blocks or tissue sections from initial or upon diagnosis of advanced metastatic disease are available for submission to the central laboratory within approximately 4 weeks after enrollment or approval is granted by the sponsor (upon receipt of justification why the sample is not available) - age ≥ 18 years - ECOG performance status of 0-2 - hemoglobin concentration ≥ 9 g/dL - absolute neutrophil count ≥ 1.5 x 10(9th)/L - corrected serum calcium ≤ 10 mg/dL - either serum creatinine < 2.0 x upper limit of normal OR creatinine clearance > 40 mL/min - alanine aminotransferase ≤ 2.5 times upper limit of normal or < 5.0 x ULN if the subject has documented liver metastasis or primary hepatic neoplasm - serum total bilirubin ≤ 2.5 times upper limit of normal - before any study-specific procedure, the appropriate written informed consent must be obtained

- active brain metastases; brain metastases allowed provided they have been treated with surgery and/or radiation therapy and show no evidence of progression on cerebral CT or MRI scan 2 months following surgery and/or radiation therapy - concurrent severe and/or uncontrolled medical disease (e.g., uncontrolled diabetes, congestive cardiac failure, myocardial infarction within 6 months before enrollment) that could compromise participation in the study - documented history of human immunodeficiency virus infection - documented history of viral chronic hepatitis - received biologic, small molecule, immunotherapy, chemotherapy, radiotherapy or other agents to treat renal cancer within 28 days before enrollment - treated previously with c-Met or HGF targeted therapy - concurrent or prior (within 7 days before enrollment) anticoagulation therapy, except: �� Use of low-dose warfarin (< 2 mg/day) for prophylaxis against central venous catheter thrombosis or �� Use of low molecular weight heparins (LMWH, e.g., enoxaparin sodium [Lovenox] and unfractionated heparin for prophylaxis against central venous catheter thrombosis is allowed - concurrent use of hormones or other chemotherapeutic agents except for steroids given for adrenal failure and hormones administered for non-disease-related conditions (eg, insulin for diabetes); except for non-cancer reasons - concurrent palliative or therapeutic radiation therapy - currently enrolled in or has not yet completed at least 30 days since ending other investigational device or therapy, or subject is receiving other investigational agent(s) - active infection requiring treatment within 1 week before enrollment - undergone major surgery within 4 weeks before enrollment or recovering from prior surgery - past or current history of another neoplasm, except for curatively treated non-melanoma skin cancer, carcinoma in situ of the cervix and other primary solid cancer with no known active disease present and no curative treatment administered for the last 3 years - known allergy or sensitivity to any of the excipients in the investigational product to be administered - pregnant or is breast feeding - not consenting to use adequate contraceptive precautions during the course of the study and for 6 months after the last administration of investigational product: �� female subjects who are not post-menopausal (no menstrual period for a minimum of 12 months at study entry) or documented surgically sterile will not be bound to this exclusion - previously treated with AMG 102 - previously enrolled into this study - will not be available for follow-up assessments - has other disorders that compromises the ability of the subject to give written informed consent and/or comply with study procedures - unable to begin protocol specified treatment within 3 days after enrollment