Moderate Rheumatoid Arthritis (RA) with Etanercept (Enbrel)

- Male or female ≥18 and ≤80 years of age at time of screening - Diagnosed with rheumatoid arthritis as determined by meeting 1987 American College of Rheumatology (ACR) classification criteria and has had rheumatoid arthritis for at least 6 months - Moderate rheumatoid arthritis during screening, as defined by a disease activity score (28 joint) calculated using the C-reactive protein formula (DAS28-CRP) > 3.2 and ≤ 5.1 - Active rheumatoid arthritis defined as ≥ 3 swollen joints (out of 28 joints examined) and ≥ 3 tender/painful joints (out of 28 joints examined) at screening and baseline. (A full 66/68 count joint count will be performed at baseline, but only joints in the 28-count joint count will be considered for eligibility. The 28-joint count consists of the finger joints excluding the distal interphalangeal joints, the wrists, elbows, shoulders, and knees) - Must be currently taking a DMARD such as methotrexate, sulfasalazine, leflunomide, minocycline, and/or hydroxychloroquine

- Prosthetic joint infection within 5 years of screening or native joint infection within 1 year of screening - Class IV rheumatoid arthritis according to ACR revised response criteria - Any active infection (including chronic or localized infections) for which anti-infectives were indicated within 28 days prior to first investigational product dose - Previously used more than one experimental biologic DMARD. Patient with prior use of no more than one experimental biologic is permitted if the subject received no more than 8 weeks of treatment. The use of the experimental biologic must not have occurred within 2 months of the first dose of investigational product - Previously used more than one commercially available biologic DMARD. Subject with prior use of no more than one commercially available biologic is permitted if the patient received no more than 8 weeks of treatment and did not discontinue because of lack of effect. The use of the biologic must not have occurred within 2 months of the first dose of investigational product. Acceptable prior use of biologics include the following examples: - No more than 4 injections of adalimumab - No more than 8 (50 mg) injections of etanercept - No more than 2 infusions of infliximab - No more than 2 infusions of abatacept - Additional inclusion (exclusion) criteria may apply