Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects with Various Degrees of Renal Insufficiency

-Men or women ≥18 years of age -Laboratory test values (clinical chemistry and hematology)within normal limits, (other than test values out of the normal range for subjects with CKD [groups 1 and 3 through 5]), or clinically acceptable to the investigator and sponsor at screening and day -3 -Free of any clinically significant disease or condition(s) (other than that consistent with CKD for subjects in groups 1 and 3 through 5) that require a physician’s care and/or would interfere with the evaluations, procedures, or participation in the study per the investigator’s discretion;

-Subjects whose second MDRD eGFR result during the screening period is not within 10% of the first eGFR result -Subjects who have received a functioning renal transplant within the past year -Subjects with ESRD who do not have a functioning hemodialysis access -Subjects with hemodynamic instability during hemodialysis -Subjects whose renal insufficiency is due to active autoimmune renal disease -Subjects with renal insufficiency or ESRD requiring hemodialysis and Troponin I > upper limit of normal (ULN) at screening or day -3 -Subjects with history of heart disease or unstable angina within the last 3 months -Subjects with uncontrolled diabetes (Hb1Ac > 8%) and/or subjects who are able but unwilling to adhere to the required fasting intervals