AMG 151 Amgen Protocol Number 20100761

- Age 18 to 75 years, inclusive - Diagnosis of type 2 diabetes mellitus - HbA1c levels 7.5% to 11.0%, inclusive, at screening - Fasting C-peptide levels ≥ 0.2 nmol/L at screening - BMI ≥ 25 to < 45 kg/m2 at screening - Treated with metformin monotherapy for at least 3 months prior to randomization; the metformin dose must be ≥ 850 mg daily for at least 2 months immediately prior to randomization - If a subject is being treated for hyperlipidemia or hypertension they should be on stable medication for 30 days before randomization - Subject has provided informed consent.

- History of type 1 diabetes - History of significant weight gain or loss (> 10%) during the 4 weeks before randomization - Use of any weight loss medication (over the counter or prescription) within 60 days of randomization - Use of any oral or injectable anti-hyperglycemic medication (other than metformin) within 3 months prior to randomization - Use of chronic and/or continuous insulin administration for > 15 days in an outpatient setting to achieve and maintain glycemic control prior to randomization - Have had 2 or more emergency room visits or hospitalizations due to poor glucose control in the past 6 months - Have had more than 1 episode of severe hypoglycemia within 6 months prior to entry into the study, or currently diagnosed as having hypoglycemia unawareness - Evidence of active infections that can interfere with the study - Presence of clinically significant organ system disease that is not stabilized or may interfere with the study - Currently receiving immunosuppressive therapy - History of positive HIV, chronic hepatitis B or C, or cirrhosis - Have symptomatic congestive heart failure or a history of myocardial infarction, unstable angina, or decompensated congestive heart failure or stroke in the past 6 months prior to screening. - History of gastric surgery, vagotomy, bowel resection or any surgical procedure that might interfere with gastrointestinal motility, pH or absorption - Any finding on the screening ECG that in the opinion of the investigator requires further cardiovascular evaluation - Poorly controlled hypertension defined as diastolic pressure > 100 mm Hg or systolic pressure > 160 mm Hg (assessed on two separate occasions during the screening period) - Malignancy (other than resected cutaneous basal or cutaneous squamous cell carcinoma, or treated in situ cervical cancer considered cured) within 5 years of screening visit (if a malignancy occurred > 5 years ago, subject is eligible with documentation of disease-free state since treatment) - Use of known inhibitors or inducers of CYP3A4 are not permitted 30 days prior to randomization