Study Complete
Sponsor ID
20130385
Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in high cardiovascUlar risk SubjectsEBBINGHAUS
Study Details
This study evaluated change over time in neurocognitive testing in patients receiving statin therapy in combination with evolocumab (AMG 145), compared with patients receiving statin therapy in combination with placebo.
Protocol Summary
Primary Outcome Measures
Mean Change from baseline over time in Spatial Working Memory (SWM) index of executive function
Timeframe: Mean of data collected over the study duration (up to 4 years)
Secondary Outcome Measures
Mean Change from baseline over time in Spatial Working Memory (SWM) between-errors score
Timeframe: Mean of data collected over the study duration (up to 4 years)
Mean Change from baseline over time in Paired Associated Learning (PAL) total errors adjusted.
Timeframe: Mean of data collected over the study duration (up to 4 years)
Mean Change from baseline over time in Reaction Time (RTI) median 5-choice reaction time
Timeframe: Mean of data collected over the study duration (up to 4 years)
Study Documents
Study Synopsis
Available Language(s): English
Locations
Location
Research Site
Daytona Beach, FL, United States, 32117
Status
Completed
Location
Research Site
Voorhees, NJ, United States, 08043
Status
Recruiting
Location
Research Site
Fort Mill, SC, United States, 29707
Status
Recruiting
Location
Research Site
Christchurch, New Zealand, 8011
Status
Recruiting
Location
Research Site
Owensboro, KY, United States, 42303
Status
Recruiting
Location
Research Site
Hollywood, FL, United States, 33021
Status
Recruiting
Showing {first} - {last} of {total} Results