Terminated/Withdrawn
Sponsor ID
20180224

Single and Multiple Ascending Dose Study of AMG 171 in Subjects with Obesity

Sponsor ID
20180224
Clinicaltrials.gov ID
NCT04199351
EUCTIS ID
N/A
EudraCT ID
N/A

Study Details

To assess the safety and tolerability of AMG 171 as single or multiple doses in subjects with obesity

Additional Study Details

Phase
Phase 1
Product
AMG 171
Type
Interventional
Masking
Double (Participant, Investigator)
Enrollment
60
Additional Study Details

Protocol Summary

Primary Outcome Measures

Subject incidence of treatment-emergent adverse events.

Timeframe: through study completion, up to day 207

Subject incidence of clinically significant changes in laboratory safety test results

Timeframe: through study completion, up to day 207

Subject incidence of clinically significant changes in vital sign assessments

Timeframe: through study completion, up to day 207

Subject incidence of clinically significant changes in 12-lead electrocardiogram (ECG) assessments

Timeframe: through study completion, up to day 207

Secondary Outcome Measures

Pharmacokinetic parameter - maximum plasma concentration (Cmax)

Timeframe: through study completion, up to day 207

Pharmacokinetic parameter - time to maximum plasma concentration (Tmax)

Timeframe: through study completion, up to day 207

Pharmacokinetic parameter - area under the plasma concentration-time curve (AUC)

Timeframe: through study completion, up to day 207

Incidence of anti-AMG 171 antibody formation

Timeframe: through study completion, up to day 207

Locations

Location
Status
Contact Us
Location
Orange County Research Center
Tustin, CA, United States, 92780
Status
Recruiting
Location
Anaheim Clinical Trials
Anaheim, CA, United States, 92801
Status
Recruiting
Location
Clinical Pharmacology of Miami, LLC
Miami, FL, United States, 33014
Status
Recruiting